| Partidos por jornada |
| 1 2 3 4 5 6 |
| Calendario: | Por jornada Por fecha Actual | Estad.jugadores: |
| J | Fecha | Local | Res. | Visitante | Hora | Lugar | |
| Jornada 1 | |||||||
| 8/16/2011 | Santos Torreon | 3 - 2 | Real Espana | 20:00 | Estadio Corona | ||
| 8/16/2011 | Alajuela | 1 - 0 | Morelia | 22:00 | Alejandro Morera S | ||
| 8/16/2011 | Galaxy | 2 - 0 | Motagua | 22:00 | Home Depot Center | ||
| 8/16/2011 | Seattle | 4 - 1 | Comunicaciones | 22:00 | Century Link Field | ||
| 8/17/2011 | Heredia | 0 - 5 | Monterrey | 20:00 | Eladio Rosabal C | ||
| 8/17/2011 | Colorado Rapids | 3 - 2 | Metapan | 22:00 | Dick´s Sporting | ||
| 8/17/2011 | Pumas | 0 - 1 | FC Dallas | 22:00 | CU | ||
| 8/18/2011 | Tauro FC | 1 - 2 | Toronto FC | 20:00 | Rommel Fernandez | ||
| Jornada 2 | |||||||
| 8/23/2011 | Monterrey | - | Seattle | 20:00 | Tecnólogico | ||
| 8/23/2011 | Comunicaciones | - | Heredia | 22:00 | Mateo Flores | ||
| 8/23/2011 | Real Espana | - | Colorado Rapids | 22:00 | Olímpico | ||
| 8/24/2011 | Toronto FC | - | FC Dallas | 20:00 | BMO Field | ||
| 8/24/2011 | Metapan | - | Santos Torreon | 22:00 | Jorge Calero | ||
| 8/25/2011 | Tauro FC | - | Pumas | 20:00 | Rommel Fernandez | ||
| 8/25/2011 | Galaxy | - | Alajuela | 22:00 | Home Depot Center | ||
| 8/25/2011 | Morelia | - | Motagua | 22:00 | Morelos | ||
| Jornada 3 | |||||||
| 9/13/2011 | Morelia | - | Galaxy | 20:00 | Morelos | ||
| 9/13/2011 | Colorado Rapids | - | Santos Torreon | 22:00 | Dick´s Sporting | ||
| 9/13/2011 | Real Espana | - | Metapan | 22:00 | Olímpico | ||
| 9/14/2011 | FC Dallas | - | Tauro FC | 20:00 | Pizza Hut Park | ||
| 9/14/2011 | Pumas | - | Toronto FC | 20:00 | CU | ||
| 9/14/2011 | Comunicaciones | - | Monterrey | 22:00 | Mateo Flores | ||
| 9/14/2011 | Heredia | - | Seattle | 22:00 | Eladio Rosabal C | ||
| 9/15/2011 | Motagua | - | Alajuela | 22:00 | Nacional | ||
| Jornada 4 | |||||||
| 9/20/2011 | Monterrey | - | Comunicaciones | 20:00 | Tecnólogico | ||
| 9/20/2011 | Toronto FC | - | Tauro FC | 20:00 | BMO Field | ||
| 9/20/2011 | Seattle | - | Heredia | 22:00 | Century Link Field | ||
| 9/21/2011 | FC Dallas | - | Pumas | 20:00 | Pizza Hut Park | ||
| 9/21/2011 | Alajuela | - | Galaxy | 22:00 | Alejandro Morera S | ||
| 9/21/2011 | Colorado Rapids | - | Real Espana | 22:00 | Dick´s Sporting | ||
| 9/22/2011 | Santos Torreon | - | Metapan | 20:00 | Estadio Corona | ||
| 9/22/2011 | Motagua | - | Morelia | 22:00 | Nacional | ||
| Jornada 5 | |||||||
| 9/27/2011 | Toronto FC | - | Pumas | 20:00 | BMO Field | ||
| 9/27/2011 | Comunicaciones | - | Seattle | 22:00 | Mateo Flores | ||
| 9/27/2011 | Monterrey | - | Heredia | 22:00 | Tecnólogico | ||
| 9/28/2011 | Real Espana | - | Santos Torreon | 20:00 | Olímpico | ||
| 9/28/2011 | Tauro FC | - | FC Dallas | 20:00 | Rommel Fernandez | ||
| 9/28/2011 | Galaxy | - | Morelia | 22:00 | Home Depot Center | ||
| 9/28/2011 | Metapan | - | Colorado Rapids | 22:00 | Jorge Calero | ||
| 9/29/2011 | Alajuela | - | Motagua | 22:00 | Alejandro Morera S | ||
| Jornada 6 | |||||||
| 10/18/2011 | FC Dallas | - | Toronto FC | 20:00 | Pizza Hut Park | ||
| 10/18/2011 | Morelia | - | Alajuela | 20:00 | Eladio Rosabal C | ||
| 10/18/2011 | Seattle | - | Monterrey | 22:00 | Century Link Field | ||
| 10/19/2011 | Santos Torreon | - | Colorado Rapids | 20:00 | Estadio Corona | ||
| 10/19/2011 | Heredia | - | Comunicaciones | 22:00 | Eladio Rosabal C | ||
| 10/19/2011 | Pumas | - | Tauro FC | 22:00 | CU | ||
| 10/20/2011 | Metapan | - | Real Espana | 20:00 | Jorge Calero | ||
| 10/20/2011 | Motagua | - | Galaxy | 22:00 | Nacional |