| J | Fecha | Local | Res. | Visitante | Hora | Nota | Lugar | |
| 16 | 4/9/2011 | Marathón | 0 - 1 | Olimpia | 19:30 | 0 | Francisco Morazán | |
| 16 | 4/9/2011 | Victoria | 3 - 3 | Necaxa | 19:30 | 0 | Ceibeño | |
| 16 | 4/10/2011 | Dep Savio | 1 - 0 | Hispano | 14:00 | 0 | Sergio Reyes | |
| 16 | 4/10/2011 | Platense | 2 - 1 | Vida | 15:00 | 0 | Excelsior | |
| 16 | 4/10/2011 | Motagua | 2 - 3 | Real España | 16:00 | 0 | Nacional |